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A pivot from synaptic monoamine processes to further downstream processes: The impact of ketamine research
Author(s) -
Steelman Brittany Carnley
Publication year - 2019
Publication title -
perspectives in psychiatric care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.538
H-Index - 35
eISSN - 1744-6163
pISSN - 0031-5990
DOI - 10.1111/ppc.12317
Subject(s) - ketamine , antidepressant , nmda receptor , monoamine neurotransmitter , depression (economics) , neuroscience , psychology , mood , medicine , psychiatry , psychotherapist , anxiety , serotonin , receptor , economics , macroeconomics
Purpose Currently only one‐third of patients treated for depression enjoy complete remission of their negative symptoms. This paper explores ketamine research as it applies to understanding and treating mood illnesses. Conclusions Ketamine's rapid antidepressant effect implicates downstream signal transduction involving the spontaneous transmissions associated with ketamine's action at the NMDA receptor. Practice Implications Better understanding of brain neuropathophysiology offers hope for symptom relief to those living with affective illness refractory to currently available medical management.