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Ropinirole in Bipolar Disorder: Rate of Manic Switching and Change in Disease Severity
Author(s) -
Capote Horacio A.,
Rainka Michelle,
Westphal Erica S.,
Beecher Jonathan,
Gengo Francis M.
Publication year - 2018
Publication title -
perspectives in psychiatric care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.538
H-Index - 35
eISSN - 1744-6163
pISSN - 0031-5990
DOI - 10.1111/ppc.12205
Subject(s) - young mania rating scale , ropinirole , mania , bipolar disorder , clinical global impression , psychology , rating scale , psychiatry , bipolar i disorder , medicine , disease , mood , developmental psychology , levodopa , alternative medicine , pathology , parkinson's disease , placebo
PURPOSE To determine the effects of ropinirole on manic switching and disease severity in bipolar disorder. DESIGN AND METHODS A cross‐sectional survey was conducted in 23 bipolar depressed patients using ropinirole combination therapy (Young Mania Rating Scale [YMRS], Bipolar Inventory of Symptoms Scale [BISS]). Retrospective Clinical Global Impression of Change (CGI‐C) and CGI‐S (Severity) were captured via chart review. FINDINGS One patient (4.3%) experienced induction of mania (YMRS). All patients responded or partially responded to ropinirole (CGIs). YMRS and BISS mania scores were correlated. PRACTICE IMPLICATIONS Ropinirole has a low rate of manic switching and significantly reduces bipolar depression severity.