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Pulmonary infarction caused by sarcoidosis vascular involvement: A case report
Author(s) -
Tasaki Takashi,
Hatanaka Kazuhito,
Kitazono Ikumi,
Noguchi Hirotsugu,
Tabata Kazuhiro,
Higashi Michiyo,
Maeda Kouki,
Yokose Tomoyuki,
Uekusa Toshimasa,
Tanimoto Akihide
Publication year - 2021
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.13104
Subject(s) - sarcoidosis , medicine , pathology , infarction , granuloma , lung , adventitia , myocardial infarction , cardiology
Sarcoidosis is a systemic granulomatous disease. In pulmonary sarcoidosis, granulomatous vascular involvement is a common feature that occurs in all types of vessels, including large elastic arteries to venules, but sarcoidosis complicated with pulmonary infarction has not been reported. We report a case of a 60 years old female, who was operated on a clinical diagnosis of lung cancer, and histological examination revealed a pulmonary infarction and sarcoidosis. In the pulmonary elastic arteries, granulomas infiltrated the adventitia and media, and caused elastic fiber collapse and destruction. Arterial occlusion by granulomas was observed in the edge of the infarcted area. It was considered that the arterial sarcoidosis granuloma involvement was the cause of pulmonary infarction. Sarcoidosis is a significant risk factor for cardiovascular events. However, pulmonary infarction is an extremely rare complication of sarcoidosis. Our case suggests that sarcoidosis may cause vascular events in the lungs.