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The significance of enhancer of zeste homolog 2 (EZH2) expression in spindle cell lesions of the breast
Author(s) -
Genco Iskender Sinan,
Hackman Kayla,
Morrar Doaa,
Jin Cao,
Santagada Eugene,
Hajiyeva Sabina
Publication year - 2021
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.13093
Subject(s) - ezh2 , expression (computer science) , pathology , cell , enhancer , biology , medicine , gene expression , genetics , computer science , gene , programming language
Spindle cell lesions of the breast are rare entities and pose a diagnostic challenge for pathologists due to overlapping morphologic and immunohistochemical features. We evaluated EZH2 expression in various benign (fibromatosis ( n = 8), myofibroblastoma ( n = 7), neurofibroma ( n = 1), nodular fasciitis ( n = 5), benign phyllodes tumor ( n = 18)) and malignant (malignant phyllodes tumor ( n = 8), metaplastic breast carcinoma ( n = 16) and angiosarcoma ( n = 8)) spindle cell lesions as a potential diagnostic and therapeutic marker. The EZH2 expression was evaluated semi‐quantitatively to categorize the cases as ‘low’ and ‘high’ expression. All benign lesions showed low EZH2 expression, whereas high EZH2 expression was observed in the majority (28/32; 88%) of malignant lesions. The study results suggest that EZH2 may be used both as an additional diagnostic tool to reach an accurate diagnosis of the spindle cell lesions of the breast and as a therapeutic target for the malignant lesions.