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High‐grade neuroepithelial tumor with BCL6 corepressor‐alteration presenting pathological and radiological calcification: A case report
Author(s) -
Ishi Yukitomo,
Shimizu Ai,
Takakuwa Emi,
Sugiyama Minako,
Okamoto Michinari,
Motegi Hiroaki,
Hirabayashi Shinsuke,
Cho Yuko,
Iguchi Akihiro,
Manabe Atsushi,
Nobusawa Sumihito,
Tanaka Shinya,
Yamaguchi Shigeru
Publication year - 2021
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.13083
Subject(s) - pathology , calcification , neuroepithelial cell , pathological , medicine , biology , neural stem cell , genetics , stem cell
A 5‐year‐old girl presented with headache and vomiting. Head computed tomography and magnetic resonance imaging showed a right frontal lobe tumor with marked calcification. The patient underwent resection surgery with suspicion of anaplastic ependymoma, and the tumor was gross totally removed. Pathological examination revealed areas of dense tumor cells with a high nucleocytoplasmic ratio and myxoid areas consisting of tumor cells with a round‐shaped nucleus and eosinophilic cytoplasm. Perivascular pseudorosette, necrosis, circumscribed growth, and microcalcification were also observed. Immunohistochemistry demonstrated negative staining for glial fibrillary protein and epithelial membrane antigen. Diagnosis of a high‐grade neuroepithelial tumor (HGNET) with BCL6 corepressor ( BCOR ) alteration was made based on pathological findings and internal tandem duplication in the exon 15 of BCOR . Although calcification on radiological and pathological examination is not typical, it would be essential to recognize that calcification could appear in HGNET‐ BCOR .