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High expression of Ras‐specific guanine nucleotide‐releasing factor 2 (RasGRF2) in lung adenocarcinoma is associated with tumor invasion and poor prognosis
Author(s) -
Nakagawa Tomoki,
Kim YunJung,
Kano Junko,
Murata Yoshihiko,
Kosibaty Zeinab,
Noguchi Masayuki,
Sakamoto Noriaki
Publication year - 2021
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.13069
Subject(s) - guanine nucleotide exchange factor , guanine , immunohistochemistry , adenocarcinoma , cancer research , nucleotide , biology , lung , pathology , medicine , gene , genetics , cancer , signal transduction
The expression of Ras‐specific guanine nucleotide‐releasing factor 2 (RasGRF2) in lung adenocarcinomas was examined using immunohistochemistry in relation to clinicopathological characteristics and prognosis. In comparison to low expression, high expression of RasGRF2 was more closely associated with poor prognosis. Interestingly, expression of phosphorylated epithelial cell transforming 2 (pECT2), which – like RasGRF2 – is also a guanine‐nucleotide exchange factor, was also associated with prognosis, and patients with high expression of both RasGRF2 and pECT2 had a much poorer outcome than those who were negative for both.