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Clinicopathological significance of intelectin‐1 in colorectal cancer: Intelectin‐1 participates in tumor suppression and favorable progress
Author(s) -
Katsuya Narutaka,
Sentani Kazuhiro,
Sekino Yohei,
Yamamoto Yuji,
Kobayashi Go,
Babasaki Takashi,
Oue Naohide,
Amatya Vishwa Jeet,
Takeshima Yukio,
Yasui Wataru
Publication year - 2020
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.13027
Subject(s) - medicine , colorectal cancer , cancer research , immunohistochemistry , carcinogenesis , epidermal growth factor receptor , transfection , cancer , colorectal adenoma , mapk/erk pathway , pathology , cell culture , biology , kinase , microbiology and biotechnology , genetics
Intelectin‐1 (ITLN1) is an adipokine with an anti‐inflammatory function that is involved in neoplastic diseases such as pleural mesothelioma and gastric and prostate cancers. However, the expression and function of ITLN1 in colorectal cancer (CRC) remain unknown. To identify novel prognostic markers or therapeutic targets for CRC, we focused on ITLN1 protein. By immunohistochemistry, 87 (59%) of 148 CRC cases showed reduced expression of ITLN1. ITLN1‐reduced CRC cases were associated with higher M grades ( P = 0.0017) than ITLN1‐retained CRC cases. Furthermore, the cases with ITLN1 retained expression tended toward a more favorable prognosis than those with reduced expression. Cell growth of the CRC cell lines transfected with ITLN1 siRNA were greater than those of the negative control cell lines transfected with siRNA. Levels of phosphorylated epidermal growth factor receptor, Erk and Akt were higher in the CRC cells transfected with ITLN1 siRNA than in control cells. Immunohistochemical analysis of human colorectal polyp specimens also revealed a sequential decrease in the expression of ITLN1 through both the conventional adenoma–carcinoma pathway and the serrated pathway. These results indicated that ITLN1 might play an important role in regulating colorectal tumorigenesis.