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Co‐occurrence of EBV‐positive classic Hodgkin lymphoma and B‐cell lymphomas of different clonal origins: A case report and literature review
Author(s) -
Karube Kennosuke,
Takatori Mitsuyoshi,
Kohno Kei,
Tomoyose Takeaki,
Ohshiro Kazuiku,
Nakazato Iwao
Publication year - 2020
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.13012
Subject(s) - lymphoma , lymphoproliferative disorders , mucocutaneous zone , epstein–barr virus , pathology , virus , b cell , biology , gene rearrangement , immunoglobulin heavy chain , polymerase chain reaction , gene , antibody , immunology , medicine , disease , genetics
Abstract Although cases with metachronous or synchronous co‐occurrence of classic Hodgkin lymphoma (CHL) and B‐cell non‐Hodgkin lymphoma (B‐NHL) have been reported, few reports have analyzed the clonal relationship between both lesions in detail, especially in Epstein–Barr virus (EBV)‐positive settings. Here, we report a case of a 38‐year‐old male with CHL, followed by the recurrence of EBV‐positive mucocutaneous ulcers of the large intestine and EBV‐positive diffuse large B‐cell lymphoma in the liver. Surprisingly, polymerase chain reaction analysis for immunoglobulin heavy chain gene rearrangement revealed that all lesions were clonally distinct. We further reviewed the literature on synchronous and metachronous co‐occurrence of CHL and B‐NHL in EBV‐positive settings. In contrast to EBV‐negative settings, all evaluable cases showed clonally distinct multiple lesions. These findings suggest that histologically and clonally distinct B‐cells could simultaneously proliferate in EBV‐associated settings, providing a new insight into the pathogenesis of EBV‐associated lymphoproliferative disorders.