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Prognostic impact of 8‐hydroxy‐deoxyguanosine and its repair enzyme 8‐hydroxy‐deoxyguanosine DNA glycosylase in hepatocellular carcinoma
Author(s) -
Yugawa Kyohei,
Itoh Shinji,
Yoshizumi Tomoharu,
Yoshiya Shohei,
Takeishi Kazuki,
Toshima Takeo,
Harada Noboru,
Ikegami Toru,
Kohashi Kenichi,
Oda Yoshinao,
Mori Masaki
Publication year - 2020
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12952
Subject(s) - oxidative stress , hepatocellular carcinoma , deoxyguanosine , dna glycosylase , medicine , pathology , immunohistochemistry , cirrhosis , 8 hydroxy 2' deoxyguanosine , gastroenterology , dna damage , dna repair , cancer research , biology , dna oxidation , dna , biochemistry , oxidative damage
Hepatocellular carcinoma (HCC) has a poor prognosis in the setting of chronic inflammation and fibrosis, both of which promote nuclear DNA oxidative damage. 8‐hydroxy‐deoxyguanosine (8‐OHdG) DNA glycosylase (OGG1) enhances the repair of 8‐OHdG, which is the primary oxidative stress‐induced mutation that leads to malignant alterations. This study aims to clarify the relationships between oxidative stress‐induced factors and HCC progression. The clinicopathological factors were compared with immunohistochemistry OGG1 and 8‐OHdG expressions in 86 resected HCC specimens. High 8‐OHdG expression was associated with high serum aspartate transaminase and total bilirubin levels, as well as a low platelet count, compared with low 8‐OHdG expression. Histological liver cirrhosis and poor differentiation were more frequent in patients with high 8‐OHdG expression than in those with low 8‐OHdG expression. The 8‐OHdG was negatively correlated with OGG1 expression in HCC patients. Therefore, we classified the patients into two groups, low OGG1/high 8‐OHdG group and the other group. The patients with low OGG1/high 8‐OHdG expressions had worse prognosis than those with the other expressions. Our results showed that low OGG1/high 8‐OHdG expressions in nuclei influence HCC patient outcomes. Evaluating the patterns of OGG1 and 8‐OHdG expressions might provide pivotal prognostic biomarkers in patients with HCC.