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Controversial issues in soft tissue solitary fibrous tumors: A pathological and molecular review
Author(s) -
Machado Isidro,
NietoMorales Gema,
Cruz Julia,
Navarro Samuel,
Giner Francisco,
Ferrandez Antonio,
LópezSoto María Victoria,
Lavernia Javier,
LlombartBosch Antonio
Publication year - 2020
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12894
Subject(s) - risk stratification , malignancy , pathological , solitary fibrous tumor , pathology , broad spectrum , malignant transformation , medical diagnosis , differential diagnosis , molecular pathology , medicine , biology , chemistry , gene , biochemistry , stem cell , cd34 , combinatorial chemistry , genetics
The clinical evolution of solitary fibrous tumor (SFT) remains unclear. Although various clinical, morphological and molecular criteria may indicate increased risk of malignancy, some SFT can still progress despite having a clearly benign appearance. Various risk stratification systems have been proposed, but unfortunately they are not sufficient to precisely determine the malignant potential. In this review, we discuss current knowledge on SFT, focusing on the following controversial issues: (i) the diverse morphologic spectrum: ‘ the great simulator; ’ (ii) malignant transformation or dedifferentiation; (iii) current risk stratification systems; and (iv) molecular factors associated with clinical evolution. The morphological spectrum of SFT and the list of differential diagnoses continue to expand. Both have increased considerably since the first descriptions of specific molecular alterations. A classification of malignant SFT should not be based on histology alone. The correlation of all pathological and molecular factors is recommended; its inclusion in risk stratification systems may help to improve diagnosis and prognosis.