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The approach of scratch‐imprint cytology: Is it an alternative to frozen section for intraoperative assessment of pulmonary lesions?
Author(s) -
Sugiyama Tomoko,
Tajiri Takuma,
Fujita Hirotaka,
Hiraiwa Shinichiro,
Toguchi Suguru,
Nomura Nozomi,
Machida Tomohisa,
Natsuyama Yuki,
Aruga Naohiro,
Matsumoto Tomohiro,
Suga Atsushi,
Nakagawa Tomoki,
Hasebe Terumitsu,
Yamada Shyunsuke,
Iwazaki Masayuki,
Nakamura Naoya
Publication year - 2020
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12878
Subject(s) - medicine , malignancy , pathological , frozen section procedure , radiology , medical diagnosis , diagnostic accuracy , cytology , lesion , pathology
To address the diagnostic performance of scratch‐imprint cytology (SIC), in this study we compared intraoperative diagnoses of pulmonary lesions between SIC and frozen section histology (FSH) for accuracy with respect to the final pathological diagnosis. We histologically divided 206 pulmonary lesions (resected surgically) into two groups (benign and malignant) and compared each intraoperative diagnosis by SIC and FSH with the final pathological diagnoses. We also examined the radiological existence of pure ground‐glass opacity (GGO) nodules in each group. The diagnostic sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 91.5%, 100%, 100%, 63.6%, and 92.6%, respectively for SIC, and 98.2%, 100%, 100%, 92.1% and 98.5%, respectively, for FSH. Thus, we concluded that diagnosis by SIC is reliable for malignancy, but not for benign lesions. All pure GGO nodules (19; 9.2%) were noninfectious and malignant with a high accuracy of FSH diagnosis (100%), in comparison with those of low accuracy with a SIC diagnosis (57.9%). SIC can be an appropriate intraoperative diagnostic tool where multiple cytotechnologists observe intraoperative SIC preparations scratched evenly across the whole lesion including the peripheral area of the mass.