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Proportion of goblet cell is associated with malignant potential in invasive mucinous adenocarcinoma of the lung
Author(s) -
Oki Tomonari,
Aokage Keiju,
Ueda Takuya,
Sugano Masato,
Tane Kenta,
Miyoshi Tomohiro,
Kojima Motohiro,
Fujii Satoshi,
Kuwata Takeshi,
Ochiai Atsushi,
Funai Kazuhito,
Tsuboi Masahiro,
Ishii Genichiro
Publication year - 2019
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12853
Subject(s) - goblet cell , adenocarcinoma , stromal cell , stroma , pathology , univariate analysis , mucin 2 , lung cancer , medicine , biology , immunohistochemistry , cancer , epithelium , multivariate analysis , gene expression , gene , biochemistry
Invasive mucinous adenocarcinoma (IMA) is a newly classified variant of lung adenocarcinoma. The aim of this study was to examine the correlation between the proportion of goblet cells and the clinicopathological characteristics of IMA. Ninety‐nine patients with stage I IMA were included in this study. We estimated prognostic impact of goblet cell proportion. We classified them into two groups: the cases with a high goblet cell proportion (HGP, goblet cell proportion ≥80%) and the cases with a low goblet cell proportion (LGP, goblet cell proportion ≤30%), and compared the expression levels of five cancer progression markers and the number of tumor‐promoting stromal cells between the two groups. Univariate and multivariate analysis revealed that the goblet cell proportion was a prognostic factor for recurrence free survival ( P < 0.01) and overall survival ( P = 0.01). The expression levels of the cancer stem cell‐related marker, ALDH‐1, and proliferation‐related marker, geminin were significantly higher in the LGP group than in the HGP group. CD204+ tumor‐associated macrophages were significantly more in the LGP stroma than the HGP stroma. Our current study indicated that the proportion of goblet cells was correlated with the malignant potential in surgically resected IMA.