Premium
Pulmonary melanocytic nevus – A case report with a mutation analysis of common driver oncogenes
Author(s) -
Tanaka Meiro,
Matsumura Mai,
Okudela Koji,
Mitsui Hideaki,
Tateishi Yoko,
Umeda Shigeaki,
Suzuki Takehisa,
Koike Chihiro,
Kataoka Toshiaki,
Kawano Naomi,
Kojima Yui,
Osawa Hiroyuki,
Ohashi Kenichi
Publication year - 2019
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12850
Subject(s) - melanoma , nevus , medicine , melanocytic nevus , pathology , conjunctiva , v600e , dermatology , melanoma diagnosis , mutation , biology , cancer research , gene , biochemistry
Nevi are benign melanocytic tumors, and some nevi are considered to develop into malignant melanomas. Most nevi arise in the skin, but nevi occasionally occur in the conjunctiva, esophageal mucosa, or at other sites. Pulmonary melanocytic nevi are extremely rare, and only one case has been reported in the literature. Here, we present a case of pulmonary melanocytic nevus, involving a BRAF gene mutation (V600E), and we discuss the potential significance of this condition as a precursor to pulmonary malignant melanoma.