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Squamous cell carcinoma of the common bile duct: A case report with genomic profiling
Author(s) -
Knudsen Kirsten Nguyen,
Mortensen Michael Bau,
Detlefsen Sönke
Publication year - 2019
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12806
Subject(s) - pathology , common bile duct , squamous metaplasia , pancreaticoduodenectomy , basal cell , bile duct , ctcf , carcinoma , medicine , biology , gene , gastroenterology , epithelium , pancreas , gene expression , genetics , enhancer
Squamous cell carcinoma of the extrahepatic bile ducts is a very rare type of cancer with a virtually unknown pathogenesis. We present the case of a 66‐year‐old woman who underwent a pancreaticoduodenectomy with the postoperative diagnosis of squamous cell carcinoma of the common bile duct. Microscopically, the entire common bile duct showed squamous metaplasia. Besides, an invasive squamous cell carcinoma was found, stage pT3pN0. A next generation sequencing assay covering 315 tumor‐related genes revealed genomic alterations in seven genes: FBXW7, CREBBP, CTCF, FAT1, MAGI2, MLL2 , and NOTCH1 .