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Chromophobe renal cell carcinoma with sarcomatoid differentiation containing various heterologous components
Author(s) -
Hyodo Toshiki,
Kanzawa Maki,
Hara Shigeo,
Takahashi Kosuke,
Ogawa Satoshi,
Furukawa Junya,
Fujisawa Masato,
Kobayashi Anna,
Kuroda Naoto,
Itoh Tomoo
Publication year - 2018
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12704
Subject(s) - heterologous , pathology , chondrosarcoma , chromophobe cell , biology , osteosarcoma , sarcomatoid carcinoma , clear cell , renal cell carcinoma , carcinoma , medicine , biochemistry , gene
Renal cell carcinoma (RCC) occasionally has sarcomatoid differentiation and rarely contains heterologous components. We report a case of chromophobe RCC with sarcomatoid differentiation that had various heterologous components including a unique lipomatous area. The patient was an 83‐year‐old woman with a palpable mass in the left lower abdomen. Grossly, the tumor was 14 cm in diameter and had yellowish‐to‐whitish color with focal necrosis and hemorrhage. Histologically, the tumor was composed of an eosinophilic subtype of chromophobe RCC with sarcomatoid differentiation including mainly chondrosarcoma, some osteosarcoma and a lipomatous area. The heterologous components of sarcomatoid RCC are usually osteosarcoma or chondrosarcoma, and sarcomatoid RCC with multiple heterologous components is extremely rare.