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Coexistence of gastrointestinal stromal tumor and leiomyosarcoma of the stomach presenting as a collision tumor: A case report and review of literature
Author(s) -
Kitagawa Hiroki,
Kaneko Mayumi,
Kano Mikihiro,
Ibuki Yuta,
Amatya Vishwa Jeet,
Takeshima Yukio,
Hirabayashi Naoki,
Hirota Seiichi
Publication year - 2018
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12662
Subject(s) - gist , pdgfra , stromal tumor , stomach , pathology , leiomyosarcoma , medicine , wedge resection , gross examination , stromal cell , resection , surgery
Collision tumor of the stomach is rare. We report a rare case of a gastric collision tumor consisting of gastrointestinal stromal tumors (GISTs) and leiomyosarcoma (LMS). Computed tomography scan revealed a 15 cm sized mass in the posterior wall of the body of the stomach. Gross examination of the wedge resection specimen showed the tumor located in the muscularis propria with extramural protrusion into the peritoneal cavity and the gastric cavity with geographic necrosis, hemorrhage, and mucosal ulceration. Histologically, the majority of the tumor consisted of the GIST component and the minor area in the submucosal region consisted of the LMS component. The tumor showed an abrupt transition between GIST and LMS by histologically and immunohistochemically, suggesting a collision tumor. Furthermore, the GIST components exhibited a c‐ kit exon 11 mutation. On the other hand, LMS component exhibited neither c‐ kit nor platelet‐derived growth factor receptor‐alpha (PDGFRA) mutation. Here we describe a case of the collision tumor consisting of GIST and LMS and its literature review.