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Basigin expression as a prognostic indicator in stage I pulmonary adenocarcinoma
Author(s) -
Matsumoto Toshihide,
Nagashio Ryo,
Ryuge Shinichiro,
Igawa Satoshi,
Kobayashi Makoto,
Fukuda Eriko,
Goshima Naoki,
Ichinoe Masaaki,
Jiang ShiXu,
Satoh Yukitoshi,
Masuda Noriyuki,
Murakumo Yoshiki,
Saegusa Makoto,
Sato Yuichi
Publication year - 2018
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12646
Subject(s) - stage (stratigraphy) , pathology , adenocarcinoma , medicine , immunohistochemistry , lung cancer , lymphovascular invasion , proportional hazards model , survival analysis , monoclonal antibody , cancer , lung , cancer research , biology , antibody , immunology , metastasis , paleontology
We established the KU‐Lu‐8 monoclonal antibody (MoAb) using a lung cancer cell line as an antigen and a random immunization method. The KU‐Lu‐8 MoAb recognizes basigin (BSG), which is a transmembrane‐type glycoprotein that is strongly expressed on the cell membranes of lung cancer cells. This study aimed to clarify the relationships between BSG expression and clinicopathological parameters and determine the prognostic significance of BSG expression in pulmonary adenocarcinoma (AC) patients. To evaluate the significance of BSG expression in lung cancer, we immunohistochemically analyzed 113 surgically resected pulmonary adenocarcinomas, and the associations between BSG expression and various clinicopathological parameters were evaluated. Kaplan‐Meier survival analysis and Cox proportional hazards models were used to investigate the effects of BSG expression on survival. Clinicopathologically, BSG expression was significantly associated with tumor differentiation, vascular invasion, lymphatic invasion, and a poor prognosis. In particular, BSG expression was significantly correlated with poorer survival in patients with stage I AC. The high BSG expression group (compared with the low BSG expression group) exhibited adjusted hazard ratios for mortality of 4.694. BSG expression is indicative of a poor prognosis in AC patients, particularly in those with stage I disease.