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Thyroid carcinoma producing β‐human chorionic gonadotropin shows different clinical behavior
Author(s) -
Gu Haiyan,
Sui Shaofeng,
Cui Xiujie,
Han Bo,
Zhang Chunyan,
Qi Mei,
Li Congcong,
Liu Zhiyan
Publication year - 2018
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12639
Subject(s) - human chorionic gonadotropin , thyroid carcinoma , pathology , thyroid , medicine , follicular cell , follicular phase , carcinoma , anaplastic carcinoma , gonadotropin , oncology , hormone
Columnar cell variant of papillary thyroid carcinoma (CCV‐PTC) is an unusual neoplasm, the clinical behavior of which mainly depends on the encapsulation or infiltration. Patients with extensive extrathyroidal extension usually have an aggressive biological behavior. This study confirmed that beta‐human chorionic gonadotropin (β‐hCG) secreting invasive CCV‐PTC has good prognosis comparing with a cohort of follicular cell differentiated thyroid carcinoma. On the contrary, positive immunoreaction with β‐hCG was proved in three anaplastic thyroid carcinoma patients showing aggressive clinical courses. The clinicopathologic characteristics of CCV‐PTC and the paraneoplastic syndromes in follicular cell differentiated thyroid carcinoma were further summarized using literature review.