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Cyclophilin A expression and its prognostic significance in lung adenocarcinoma
Author(s) -
Nakano Noriyuki,
Sakashita Shingo,
Matsuoka Ryota,
Murata Yoshihiko,
ShibaIshii Aya,
Kobayashi Naohiro,
Sato Yukio,
Noguchi Masayuki
Publication year - 2017
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12593
Subject(s) - pathology , lung , adenocarcinoma , expression (computer science) , biology , medicine , cancer , computer science , programming language
Cyclophilin A (CypA) has been reported to be upregulated in malignant tumors. CypA expression is thought to be associated with acquisition of tumor growth and anti‐apoptotic function. Although upregulation of CypA has been reported in lung adenocarcinoma, its clinicopathological significance and roles in malignant progression remain unclear. Here we investigated the implications of CypA expression for outcome in patients with lung adenocarcinoma. Lung adenocarcinoma specimens from 198 cases were selected and reclassified according to the World Health Organization classification (4th edition) and the Noguchi classification. CypA expression was assessed by immunohistochemistry, and the H‐score was calculated on the basis of intensity and proportion. The specificity of the antibody used was confirmed by Western blotting and the cut‐off point was determined from the ROC curve. Sixty‐seven cases (33.8%) had low CypA expression (CypA‐L group) and 131 (66.2%) had high CypA expression (CypA‐H group). Many cases of adenocarcinoma in situ were CypA‐L, and advanced adenocarcinomas tended to be classified as CypA‐H. Clinically, patients with CypA‐H tumors showed a significantly poorer prognosis than those with CypA‐L tumors. This is the first investigation of the implications of the CypA expression level in terms of the clinical characteristics of resected lung adenocarcinomas.