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A case of anaplastic lymphoma kinase‐positive renal cell carcinoma coincident with Hodgkin lymphoma
Author(s) -
Oyama Yuzo,
Nishida Haruto,
Kusaba Takahiro,
Kadowaki Hiroko,
Arakane Motoki,
Daa Tsutomu,
Watanabe Dai,
Akita Yasuyuki,
Sato Fuminori,
Mimata Hiromitsu,
Yokoyama Shigeo
Publication year - 2017
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12592
Subject(s) - anaplastic lymphoma kinase , pathology , lymphoma , renal cell carcinoma , fusion gene , fluorescence in situ hybridization , giant cell , biology , cancer research , medicine , gene , lung cancer , biochemistry , malignant pleural effusion , chromosome
We report a case of ALK‐positive renal cell carcinoma coincident with Hodgkin lymphoma. The patient was a 19 year‐old‐girl without sickle cell trait. The right renal tumor was discovered concomitantly with Hodgkin lymphoma (HL). After chemotherapy for HL, right nephrectomy was performed. Microscopically, the tumor showed a solid and focally pseudo‐papillary growth pattern studded with tubular structures. Most tumor cells were small bland eosinophilic cells, but rhabdoid cells, vacuolated cells, pleomorphic multinucleated giant cells were also admixed. The variety of growth patterns and cell features led us to speculate a possibility of ALK‐positive renal cell carcinoma (ALK + RCC). ALK was immunohistochemically positive, and fluorescence in situ hybridization analysis detected a split signal of the ALK gene. We examined previously reported partner genes (STRN, TPM3, VCL and EML4) by RT‐PCR, but fusion gene was not detected. RCC showing solid or cribriform growth patterns with vacuolated cells with intracytoplamic lumina, rhabdoid cells, and mucus production indicates the possibility of ALK + RCC.