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Primary hepatic choriocarcinoma in an 83‐year‐old woman
Author(s) -
Fukagawa Akihiko,
Fujita Naoto,
Ohira Kenji,
Fujimoto Hajime,
Goto Nobuaki,
Nozawa Akinori
Publication year - 2017
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12552
Subject(s) - pathology , choriocarcinoma , cytotrophoblast , immunohistochemistry , vimentin , medicine , syncytiotrophoblast , cytokeratin , hepatocellular carcinoma , biology , placenta , fetus , pregnancy , genetics
We present a case of primary hepatic choriocarcinoma in an 83‐year‐old Japanese woman with gastric wall and lymph node metastases and a splenic vein tumor thrombus. Multiple irregular hepatic tumors with massive necrosis and hemorrhage were observed during autopsy. Syncytiotrophoblast‐like and mononucleated cytotrophoblast‐like cell morphology with focal hepatocellular carcinoma (HCC)‐like trabecular structures was observed. In immunohistochemical analyses, the tumor cells expressed human chorionic gonadotropin (hCG) and cytokeratins (AE1/AE3, CK7, CK19) but were negative for alpha‐fetoprotein (AFP), glypican‐3, and vimentin. Immunohistochemical findings did not reveal evidence of HCC or angiosarcoma. We concluded the liver tumor was primary hepatic choriocarcinoma.