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Ovarian nongestational choriocarcinoma and associated adenocarcinoma with the same germ cell origin determined by a molecular genetic approach: A case report
Author(s) -
Koyanagi Takahiro,
Fujiwara Hiroyuki,
Usui Hirokazu,
Ariga Haruko,
Machida Shizuo,
Takei Yuji,
Saga Yasushi,
Shozu Makio,
Fukushima Noriyoshi,
Niki Toshiro,
Matsubara Shigeki,
Suzuki Mitsuaki
Publication year - 2016
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12445
Subject(s) - choriocarcinoma , germ cell , adenocarcinoma , germ cell tumors , biology , chorioepithelioma , cancer research , ovarian cancer , ovary , pathology , cancer , medicine , genetics , gene , chemotherapy
Ovarian non‐gestational choriocarcinomas co‐existing with adenocarcinoma are extremely rare and have been reported as epithelial ovarian carcinomas of a “non‐germ cell origin” with “choriocarcinomatous differentiation”. Although the cellular origin of non‐gestational choriocarcinoma may be post‐meiotic ovarian germ cells or the dedifferentiation of epithelial ovarian carcinoma, detailed genetic evidence has not yet been obtained to support this. We herein present a case of ovarian non‐gestational choriocarcinoma co‐existing with adenocarcinoma in a 29‐year‐old woman. The tumor rapidly increased in size and lung metastases appeared soon after parturition. We genetically demonstrated that the cellular origin of ovarian non‐gestational choriocarcinoma was a post‐meiotic germ cell derivation using a short tandem repeat analysis. The co‐existing adenocarcinoma component was also shown to be of the same germ cell origin. These tumors showed the same homozygous pattern. A molecular genetic approach may be important for understanding the clinicopathological features of such tumors.