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Reversible sclerosing cholangitis with ulcerative colitis
Author(s) -
Kakisaka Keisuke,
Ishida Kazuyuki,
Kataoka Kojiro,
Suzuki Yuji,
Yanai Shunichi,
Kuroda Hidekatsu,
Sugai Tamotsu,
Matsumoto Takayuki,
Takikawa Yasuhiro
Publication year - 2016
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12427
Subject(s) - ulcerative colitis , medicine , prednisolone , bile duct , immunosuppression , pathology , gastroenterology , biopsy , alkaline phosphatase , lesion , infiltration (hvac) , intrahepatic bile ducts , primary sclerosing cholangitis , liver biopsy , biology , disease , biochemistry , physics , enzyme , thermodynamics
Sclerosing cholangitis (SC) with granulocytic epithelial lesion (GEL) responds well to immunosuppression therapy. We treated a 42‐year‐old Japanese female with ulcerative colitis, who was admitted for further evaluation of both an elevated alkaline phosphatase level and dilated intrahepatic bile ducts. A liver biopsy on the fourth hospital day revealed the infiltration of neutrophils into the bile duct epithelium, which was diagnosed as GEL. Because her ulcerative colitis was in an active stage, prednisolone (PSL) therapy was started. After the administration of PSL, laboratory data dramatically decreased. A liver biopsy was performed on the 66th hospital day to confirm the lesion around bile ducts in the portal tract. The infiltration of neutrophils into the bile duct epithelium disappeared after PSL administration, and IgG4‐positive plasma cells were not found in the liver. Herein, we report a rare case of GEL‐positive SC. The present case provides early evidence of treatment‐induced histological changes as well as serial changes in biochemical data during the course of immunosuppression therapy.