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IgG4 ‐related disease manifesting the gastric wall thickening
Author(s) -
Kawano Hiroo,
Ishii Aya,
Kimura Tokuhiro,
Takahashi Tsuyoshi,
Hironaka Hideharu,
Kawano Michitaka,
Yamaguchi Michiya,
Oishi Keiji,
Kubo Makoto,
Matsui Shoko,
Notohara Kenji,
Ikeda Eiji
Publication year - 2016
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12364
Subject(s) - thickening , disease , pathology , medicine , chemistry , polymer science
IgG4 ‐related disease ( IgG4 ‐ RD ) is a recently designated disease entity and its full picture has not yet been elucidated. Here, we report an unusual case of a patient with gastric wall thickening secondary to IgG4 ‐ RD . A 68‐year‐old male visited our hospital with itchy skin lesions and an episode of organizing pneumonia. On the suspicion of malignancy‐associated skin lesions, computed tomography ( CT ) was performed. The CT revealed prominent thickening of the gastric wall. Due to the possibility of malignancy, the patient underwent distal gastrectomy. Histopathological examination showed fibrosis of the submucosa and prominent thickening of the muscularis propria. Most of infiltrating cells were IgG4 ‐positive plasma cells. Post‐operative blood test revealed significantly high serum levels of total IgG and IgG4 . Based on these histological features, the patient was given a definitive diagnosis of IgG4 ‐ RD . Further accumulation of cases like the present case that develop IgG4 ‐ RD with rare manifestations would lead to the elucidation of pathogenesis.