Premium
Primary pleural angiosarcoma associated with pneumoconiosis: An autopsy case
Author(s) -
Matsuda Katsuya,
Yamaryo Takeshi,
Akazawa Yuko,
Kawakami Kenji,
Nakashima Masahiro
Publication year - 2015
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12347
Subject(s) - pathology , pneumoconiosis , medicine , cytokeratin , autopsy , vimentin , angiosarcoma , cd34 , cd31 , lung , immunohistochemistry , biology , genetics , stem cell
We report a case of pleural angiosarcoma in an adult male patient confirmed by autopsy and possibly associated with pneumoconiosis. The lesion was characterized by thickened pleura of both lungs with nodular tumors. Histologically, the tumor was composed of spindle‐to‐polygonal epithelioid cells that were positive for CD 31, CD 34, vimentin, and cytokeratin on immunohistochemical staining but were negative for calretinin. Further examination revealed mix‐dust pathological findings consistent with the existence of pneumoconiosis; dystrophic ossification, anthracosis, and fractal small dust particles were observed in the lung parenchyma and a hilar lymph node. The current case suggests that pneumoconiosis‐associated pathologies may be risk factors for the development of angiosarcoma in the pleura.