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The potential role of microRNA‐31 expression in early colorectal cancer
Author(s) -
Tateishi Yoko,
Okudela Koji,
Mitsui Hideaki,
Umeda Shigeaki,
Suzuki Takehisa,
Kojima Yoko,
Watanabe Kazuteru,
Kawano Naomi,
Endo Itaru,
Ohashi Kenichi
Publication year - 2015
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12334
Subject(s) - colorectal cancer , carcinogenesis , microrna , cancer research , real time polymerase chain reaction , pathology , reverse transcription polymerase chain reaction , immunohistochemistry , in situ hybridization , cancer , biology , mouse model of colorectal and intestinal cancer , medicine , deleted in colorectal cancer , gene expression , oncology , gene , genetics
The expression of microRNA ‐31 ( miR ‐31) has been implicated in the progression of some human malignancies including colorectal cancer. However, the clinical significance of the expression of miR ‐31 in submucosally invasive ( T 1) colorectal cancer remains unclear. The aim of the present study was to delineate the relationship between clinicopathological features and the oncogenic modulator miR ‐31 in submucosally invasive colorectal cancer. We investigated the expression of miR ‐31 in 50 submucosally invasive colorectal cancer specimens, along with the corresponding non‐tumoral mucosa specimens, using a real‐time quantitative reverse transcription‐polymerase chain reaction ( qRT ‐ PCR ). The relationships between miR ‐31 expression levels and clinicopathological characteristics were assessed. The miR ‐31 host gene locus was investigated using fluorescence in situ hybridization. qRT ‐ PCR revealed that the expression of miR ‐31 was higher in colorectal cancer tissue than in non‐tumoral tissue ( P = 0.0002). The up‐regulated expression of miR ‐31 may play an oncogenic role in the early stage of carcinogenesis in colorectal cancers.