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Low incidence of MYC / BCL2 double‐hit in B urkitt lymphoma
Author(s) -
Yoshida Maki,
Ichikawa Ayako,
Miyoshi Hiroaki,
Kiyasu Junichi,
Kimura Yoshizo,
Niino Daisuke,
Ohshima Koichi
Publication year - 2015
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12333
Subject(s) - chromosomal translocation , lymphoma , incidence (geometry) , fluorescence in situ hybridization , immunohistochemistry , biology , medicine , cancer research , pathology , gene , genetics , chromosome , physics , optics
Translocations involving MYC are highly characteristic for B urkitt lymphoma ( BL ). BCL2 expression has also been found previously in about 10 to 20% of BL cases, and BCL2 translocation is a major mechanism for the deregulation of BCL2 expression in non‐ H odgkin lymphomas. However, we know little about the incidence of MYC / BCL2 double‐hit ( DH ) in BL . We examined BL cases to determine how frequently they contained BCL2 translocations in combination with MYC translocations using fluorescence in situ hybridization. We also determined the effect of BCL2 expression on clinical outcomes of BL . BCL2 translocations were detected in 3.5% (2/57 cases) of the cases, and BCL2 expression was detected in 33%. Two cases with BCL2 translocation also showed BCL2 expression. The incidence of BCL2 expression was significantly higher in patients 16 years of age and older (46%) than in patients under 16 years of age (6%). Among patients 16 years of age and older, we did not detect significant differences in overall survival with respect to BCL2 expression status. In conclusion, BCL2 translocation is a rare cytogenetic abnormality in BL , and BL probably accounts for only a small fraction of MYC / BCL2 DH lymphomas. BCL2 expression in BL is probably not associated with BCL2 translocations.