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Differential role of gene hypermethylation in adenocarcinomas, squamous cell carcinomas and cervical intraepithelial lesions of the uterine cervix
Author(s) -
BlancoLuquin Idoia,
Guarch Rosa,
Ojer Amaya,
PérezJanices Noemí,
MartínSánchez Esperanza,
MariaRuiz Sergio,
MonrealSantesteban Iñaki,
BlancoFernandez Laura,
PernautLeza Eduardo,
Escors David,
GuerreroSetas David
Publication year - 2015
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12332
Subject(s) - dna methylation , medicine , cervical cancer , cervix , cancer , pathology , cervical intraepithelial neoplasia , methylation , cancer research , gene , biology , gene expression , biochemistry
Cervical cancer is the third most common cancer in women worldwide. The hypermethylation of P 16 , TSLC ‐1 and TSP ‐1 genes was analyzed in squamous cell carcinomas ( SCC ), cervical intraepithelial lesions ( CIN ) and adenocarcinomas ( ADC ) of the uterine cervix (total 181 lesions). Additionally human papillomavirus ( HPV ) type, EPB41L3 , RASSF1 and RASSF2 hypermethylation were tested in ADC and the results were compared with those obtained previously by our group in SCC . P 16 , TSLC ‐1 and TSP ‐1 hypermethylation was more frequent in SCCs than in CINs . These percentages and the corresponding ones for EPB41L3 , RASSF1 and RASSF2 genes were also higher in SCCs than in ADCs , except for P 16 . The presence of HPV in ADCs was lower than reported previously in SCC and CIN . Patients with RASSF1A hypermethylation showed significantly longer disease‐free survival ( P = 0.015) and overall survival periods ( P = 0.009) in ADC patients. To our knowledge, this is the first description of the EPB41L3 and RASSF2 hypermethylation in ADCs . These results suggest that the involvement of DNA hypermethylation in cervical cancer varies depending on the histological type, which might contribute to explaining the different prognosis of patients with these types of tumors.