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Aging rather than sun exposure is a major determining factor for the density of miR ‐125b ‐positive epidermal stem cells in human skin
Author(s) -
Toyokuni Shinya,
Jiang Li,
Wang Shenqi,
Hirao Ayaka,
Wada Tamae,
Soh Chieko,
Toyama Kazumi,
Kawada Akira
Publication year - 2015
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12320
Subject(s) - epidermis (zoology) , basal (medicine) , sun exposure , stem cell , human skin , skin aging , sunlight , in situ hybridization , biology , pathology , microbiology and biotechnology , andrology , anatomy , medicine , endocrinology , dermatology , biochemistry , physics , genetics , gene expression , gene , astronomy , insulin
Sunlight exposure and aging are two major factors in the deterioration of skin function. In the present study, we used eighty formalin‐fixed human skin samples from sun‐exposed and unexposed areas from old and young individuals to evaluate the presence of miR ‐125b ‐positive epidermal stem cells ( ESCs ) by in situ hybridization. miR ‐125b ‐positive ESCs were detected in the basal layer of the epidermis. The density of miR ‐125b ‐positive ESCs was significantly associated with age rather than sun exposure, whereas the density of miR ‐125b ‐positive ESCs tended to decrease in the sun‐exposed area. These data suggest the potential use of miR ‐125b as a surrogate marker for the quality of epidermal cells.