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A case of cord capillary hemangioma of the spleen: A recently proven true neoplasm
Author(s) -
Tajima Shogo,
Koda Kenji
Publication year - 2015
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12277
Subject(s) - hamartoma , pathology , capillary hemangioma , medicine , spleen , immunohistochemistry , hemangioma , lesion , cd34 , anatomy , biology , stem cell , genetics
Cord capillary hemangioma ( CCH ) of the spleen is an extremely rare lesion. Once classified under splenic hamartoma, CCH is now differentiated from hamartoma, as its clonality has recently been proven. Herein, we present the case of an incidentally found CCH , measuring 6 × 5.5 × 5 cm, in a 45‐year‐old man. He underwent splenectomy and has been recurrence‐free for 8 years. Macroscopically, the cut surface of the mass showed a central stellate scar with peripheral interspersed reddish areas of variable sizes and intervening fibrous bands. Microscopically, the mass was well demarcated from the splenic tissue. The macroscopic reddish areas were found to correspond to nodules of various sizes, which were predominantly composed of CD34 ‐expressing capillaries without the presence of CD8 ‐expressing sinuses. The relative proportion of these two types of vessels distinguishes CCH from sclerosing angiomatoid nodular transformation ( SANT ), as SANT shows the apparent presence of CD8 ‐expressing sinuses. In longstanding cases of SANT , sinuses might become ambiguous and the differences between CCH and SANT might become subtle. Nonetheless, immunohistochemistry should be performed when these conditions are suspected, since accurate distinction is usually achieved as a result.