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Results of central pathology review of prostatic biopsies in a contemporary series from a phase III , multicenter, randomized controlled trial ( SHIP0804 )
Author(s) -
Sasaki Hiroshi,
Kido Masahito,
Miki Kenta,
Aoki Manabu,
Takahashi Hiroyuki,
Dokiya Takushi,
Yamanaka Hidetoshi,
Fukushima Masanori,
Egawa Shin
Publication year - 2015
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12260
Subject(s) - grading (engineering) , concordance , medicine , pathological , biopsy , prostate cancer , prostate , multicenter study , pathology , radiology , randomized controlled trial , cancer , civil engineering , engineering
To investigate contemporary rates of variation in the biopsy G leason grading in prostate cancer, between local and central pathologists, based on central review of the pathological slides from S eed and H ormone for I ntermediate‐risk P rostate C ancer ( SHIP ) 0804, a phase III , multicenter, randomized, controlled study. From A pril 2008 to M ay 2011, 18 J apanese institutions participated. All H&E slides were reviewed independently, without clinical information, and a tumor grade was assigned according to the modified G leason grading system proposed by the I nternational S ociety of U rological P athology ( ISUP ). Prostate biopsy specimens of 642 cases were available for evaluation. An exact concordance rate of G leason score ( GS ) between local and central pathologists was determined to be 65.3%; with the under‐grading and over‐grading of grades to be 14.6% and 20.1% , respectively. The central review resulted in numbers of tumor‐bearing cores reassigned in 99 of 616 cases in which such information by the local pathologists was available (16.1%). Discordance in biopsy G leason grading was still found in one third of the cases in the SHIP0804 study. This information is valuable in extrapolating the diagnostic error range in contemporary clinical studies conducted without central pathological review.