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Four types of Ipsilateral Breast Tumor Recurrence ( IBTR ) after breast‐conserving surgery: Classification of IBTR based on precise pathological examination
Author(s) -
Sakai Takehiko,
Nishimura Seiichiro,
Ogiya Akiko,
Tanabe Masahiko,
Kimura Kiyomi,
Morizono Hidetomo,
Iijima Kotaro,
Miyagi Yumi,
Makita Masujiro,
Ito Yoshinori,
Oguchi Masahiko,
Horii Rie,
Akiyama Futoshi,
Iwase Takuji
Publication year - 2015
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12253
Subject(s) - medicine , lumpectomy , pathological , surgical margin , breast cancer , breast conserving surgery , mastectomy , pathology , radiology , oncology , cancer
We classified ipsilateral breast tumor recurrences ( IBTR s) based on strict pathological rules. Ninety‐six women who were surgically treated for IBTR were included. IBTR s were classified according to their origins and were distinguished based on strict pathological rules: relationship between the IBTR and the primary lumpectomy scar, surgical margin status of the primary cancer, and the presence of in situ lesions of IBTR . The prognosis of these subgroups were compared to that of new primary tumors ( NP ) in the narrow sense ( NP n) that occurred far from the scar. Distant‐disease free survival of IBTR that occurred close to the scar with in situ lesions and a negative surgical margin of the primary cancer ( NP occurred close to the scar, NP cs) was similar to that of NP n. In contrast, IBTR that occurred close to the scar without in situ lesions (true recurrence ( TR ) that arose from residual invasive carcinoma foci, TR inv) had significantly poorer prognosis than NPn . IBTR that occurred close to the scar with in situ lesions and a positive surgical margin of the primary cancer ( TR arising from a residual in situ lesion, TR is) had more late recurrences than NP cs. Precise pathological examinations indicated four distinct IBTR subtypes with different characteristics.

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