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Bile duct adenoma and von M eyenburg complex‐like duct arising in hepatitis and cirrhosis: Pathogenesis and histological characteristics
Author(s) -
Aishima Shinichi,
Tanaka Yuki,
Kubo Yuichiro,
Shirabe Ken,
Maehara Yoshihiko,
Oda Yoshinao
Publication year - 2014
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12209
Subject(s) - pathology , bile duct , cirrhosis , cuboidal cell , lumen (anatomy) , adenoma , hepatocellular adenoma , pathogenesis , biology , medicine , chemistry , immunohistochemistry
Morphologic features and neoplastic potentials of bile duct adenoma ( BDA ) and von M eyenburg complex ( VMC )‐like duct arising in chronic liver disease were unknown. Thirty‐five BDAs and 12 VMC ‐like duct lesions were observed in 39 cases with chronic liver disease. BDAs were divided into the EMA ‐cytoplasmic type ( n = 14) and EMA ‐luminal type ( n = 21). EMA ‐cytoplasmic BDA composed of a proliferation of cuboidal to low‐columnar cells forming an open lumen with NCAM (+)/ MUC 6(‐), resembling an interlobular bile duct. EMA ‐luminal BDA showed uniform cuboidal cells with narrow lumen, and NCAM (++)/ MUC 6(++), resembling a ductular reaction. VMC ‐like duct showed positive MUC 1 expression and negative MUC 6. The expression of S 100 P , glucose transporter‐1 ( GLUT ‐1) and insulin‐like growth factor II mRNA ‐binding protein 3 ( IMP ‐3) were not detected in three lesions. p16 expression was higher than those of the ductular reaction, and the K i67 and p53 indexes were very low (<1.0%). Large‐sized EMA ‐luminal BDA shows sclerotic stroma. We classified small nodular lesions of ductal or ductular cells in chronic hepatitis and cirrhosis into the following groups: BDA , interlobular bile duct type; BDA , ductular/peribiliary gland type; and VMC ‐like duct. They may be reactive proliferation rather than neoplastic lesions.