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Gastric‐type endocervical glandular neoplasms associated with aberrant p16 expression and K ‐ RAS gene mutation in P eutz‐ J eghers syndrome
Author(s) -
Ito Shigemi,
Tase Toru,
Satoh Kennichi,
Ueki Miyuki,
Sato Ikuro,
Sasano Hironobu
Publication year - 2014
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12173
Subject(s) - endocervix , carcinogenesis , mucin , mutation , pathology , biology , in situ hybridization , atypical hyperplasia , cancer research , gene , hyperplasia , medicine , gene expression , carcinoma , genetics , uterine cervix
In this report, unique endocervical glandular lesions exhibiting gastric differentiation were examined in a patient with P eutz‐ J eghers syndrome. The result of the human papillomavirus ( HPV ) in situ hybridization ( ISH ) for the hysterectomy specimens was negative, but they demonstrated a papillary mucinous adenocarcinoma at the proximal endocervix continuous to atypical lobular endocervical glandular hyperplasia. Both contained MUC6 ‐positive neutral mucin in cytoplasm, and showed different immunoreactivity to p16, K i‐67, and p53. Moreover, they harbored the identical K ‐ RAS gene mutation suggesting that there was a common origin. Somatic K ‐ RAS mutation and defective function of p16 may have been involved in the tumorigenesis of these unusual mucinous neoplasms.