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MUC expression in adenosquamous carcinoma of the head and neck regions of J apanese patients: Immunohistochemical analysis
Author(s) -
Kusafuka Kimihide,
Muramatsu Koji,
Iida Yoshiyuki,
Mori Keita,
Miki Tomoko,
Suda Toshihito,
Fuke Tomohito,
Kamijo Tomoyuki,
Onitsuka Tetsuro,
Nakajima Takashi
Publication year - 2014
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12144
Subject(s) - immunohistochemistry , adenosquamous carcinoma , medicine , pathology , larynx , carcinoma , lymph node , head and neck squamous cell carcinoma , laryngeal neoplasm , adenocarcinoma , tongue , head and neck , metastasis , lymph node metastasis , head and neck cancer , cancer , anatomy , surgery
Adenosquamous carcinoma ( ASC ) is a rare malignant neoplasm of the head and neck regions. We elucidated the relationship between ASC and MUC molecule expression. We selected 14 cases of ASC in the head and neck, and examined them immunohistohcmically. Seven cases of tongue, 3 cases of larynx and 4 cases of hypopharynx carcinoma were selected. Nine (64.3%) of 14 cases showed lymph node metastasis at the diagnosis. Laryngeal and hypopharyngeal cases showed a higher stage. Six cases (66.7%), all of which showed lymph node metastases, died of disease. Immunohistochemical examinations showed that ASC was positive for both markers of squamous cell carcinoma and adenocarcinoma. ASC showed positivity for MUC 1 (13 cases: 92.3%), MUC 1core (12 cases: 85.2%) and MUC 4 (12 cases: 85.7%). In rare ASC of the head and neck region, it was revealed that MUC 1 and MUC 4 expression might be associated with its nodal status.