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De novo hairy cell leukemia with a major BCR / ABL 1 rearrangement: A case report with a literature review
Author(s) -
Won YoungWoong,
Kim Sung Jong,
Park Tae Sung,
Oh Seung Hwan,
Wan Thomas S.K.,
Baek Eun Jung
Publication year - 2014
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12143
Subject(s) - hairy cell leukemia , myeloid leukemia , breakpoint cluster region , clone (java method) , gene rearrangement , leukemia , cancer research , medicine , abl , cladribine , biology , immunology , receptor , gene , genetics , tyrosine kinase
Hairy cell leukemia ( HCL ) is a very rare mature B ‐cell neoplasm and its simultaneous occurrence with chronic myeloid leukemia has been reported in only three cases. The pathogenesis and relationship of the two diseases are not clear. Here we report a case of HCL expressing a BCR / ABL 1 clone, which showed molecular remission of the fusion clones and achieved partial remission over nine months of cladribine therapy. After a thorough analysis of previous studies and the results of this patient, we speculate that a subclone evolved to have an additional genetic BCR / ABL 1 rearrangement. We also review all published literature on HCL with BCR / ABL 1 rearrangement and discuss the pathophysiology of these unusual cases.