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BCL 10 as a useful marker for pancreatic acinar cell carcinoma, especially using endoscopic ultrasound cytology specimens
Author(s) -
Hosoda Waki,
Sasaki Eiichi,
Murakami Yoshiko,
Yamao Kenji,
Shimizu Yasuhiro,
Yatabe Yasushi
Publication year - 2013
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12045
Subject(s) - pathology , serous fluid , immunohistochemistry , pancreas , kras , endoscopic ultrasound , adenosquamous carcinoma , fine needle aspiration , adenocarcinoma , medicine , biopsy , cancer , colorectal cancer , surgery
Acinar cell carcinomas ( ACCs ) of the pancreas are characterized by the histological and immunohistochemical features of acinar cell differentiation. Recently, BCL 10, originally identified as a recurrent t(1;14)(p22;q32) translocation in MALT B ‐cell lymphoma, was found to be immunohistochemically positive in some solid tumors, including ACC . To evaluate its diagnostic efficacy, we performed BCL 10 immunohistochemistry and evaluated molecular markers correlated to pancreatic tumor lineages (neuroendocrine markers and a mutation analysis of KRAS and GNAS ) using samples from 126 pancreatic tumors (17 ACCs , 24 pancreatic ductal adenocarcinomas, 4 adenosquamous carcinomas, 9 intraductal papillary mucinous neoplasms, 10 mucinous cystic neoplasms, 44 neuroendocrine tumors, 9 serous cystic tumors and 10 solid‐pseudopapillary neoplasms). BCL 10 was exclusively expressed in normal acini. In pancreatic tumors, 14 of 17 (82%) ACCs and 2 of 4 (50%) adenosquamous carcinomas were positive, while the other subtypes were almost negative. We subsequently examined the diagnostic utility of BCL 10 in endoscopic ultrasound‐guided fine‐needle aspiration ( EUS‐FNA ) specimens using 57 pancreatic tumors. BLC 10 correctly identified ACCs (9/13) and adenosquamous carcinomas (2/4) but none of the other subtypes ( n = 41). Therefore, we suggested that BCL 10 expression is a useful marker for acinar cell differentiation, particularly in the diagnosis of EUS‐FNA specimens.