Premium
Complement split product C 4d deposition in placenta in systemic lupus erythematosus and pregnancy‐induced hypertension
Author(s) -
Minamiguchi Sachiko,
Mikami Yoshiki,
Nakajima Naoki,
Salah Adeeb,
Kondoh Eiji,
Tatsumi Keiji,
Konishi Ikuo,
Haga Hironori
Publication year - 2013
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12041
Subject(s) - medicine , placenta , syncytiotrophoblast , pregnancy , gestation , intrauterine growth restriction , gestational age , gestational hypertension , immunohistochemistry , gastroenterology , fetus , obstetrics , biology , genetics
Systemic lupus erythematosus ( SLE ) and pregnancy‐induced hypertension ( PIH ) are related to premature delivery and intrauterine growth restriction ( IUGR ), and share histological findings of the placenta. Association with complement dysregulation has been reported in pregnancy for both disorders. The purpose of this study was to investigate the utility of C 4d immunohistochemistry for placentas with SLE ‐ and PIH ‐associated pregnancy. C4d staining was performed on paraffin‐embedded tissue of placentas from 26 patients with SLE , 26 with PIH , and 25 control cases. We used the H ‐score with a range of 0–300 for the evaluation of C 4d immunoreactivity. Placentas of SLE and PIH cases showed a higher H ‐score than control cases (average, SLE , 38.3 ( P < 0.05); PIH , 17.8; control, 1.68), with linear staining on the membrane of syncytiotrophoblast. C4d‐high groups comprised 50% (12/26) of SLE and 35% (9/26) of PIH cases, with H ‐scores ranging 14–270 and 15–170. C4d‐high groups were significantly associated with low‐placental weights and low birth weight in both SLE and PIH ( P < 0.05), and lower gestational age ( P < 0.05) in PIH cases. These results suggest that C 4d might be utilized as a biomarker evaluating the subsequent risk for IUGR and disease control during the gestation period in these patients.