Premium
Expression of the potential cancer stem cell markers, CD 133, CD 44, ALDH 1, and β ‐catenin, in primary lung adenocarcinoma —their prognostic significance
Author(s) -
Okudela Koji,
Woo Tetsukan,
Mitsui Hideaki,
Tajiri Michihiko,
Masuda Munetaka,
Ohashi Kenichi
Publication year - 2012
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12019
Subject(s) - cd44 , hazard ratio , adenocarcinoma , confidence interval , lung cancer , cancer stem cell , pathology , medicine , cancer research , lung , immunohistochemistry , cell , oncology , chemistry , cancer , biochemistry
The present study investigated expression profiles of the potential CSC markers including CD 133, CD 44, ALDH 1, and β‐catenin, and evaluated their prognostic value in lung adenocarcinomas. One‐hundred‐and‐seventy‐seven tumors (stage I ) were immunohistochemically examined for the expression of these markers, and thresholds to subdivide expression levels were determined using receiver operating characteristics curves. Tumors with high levels of CD 133 (adjusted hazard ratio ( HR ) 4.55 (95% confidence interval ( CI ) 1.26–16.40, P = 0.021), CD 44 ( HR 3.73, 95% CI 1.20–11.58, P = 0.023) or ALDH 1 ( HR 3.61, 95% CI 1.09–12.3, P = 0.036), but not β‐catenin ( HR 2.43, 95% CI 0.59–10.8, P = 0.220), showed a significantly higher risk of recurrence than the corresponding low expressers. In conclusion, levels of CD 133, CD 44, and ALDH 1 had independent prognostic value to predict the recurrence of lung adenocarcinoma.