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Fascin expression is related to poor survival in gastric cancer
Author(s) -
Kim Su Jin,
Kim Dae Cheol,
Kim Min Chan,
Jung Ghap Joong,
Kim Ki Han,
Jang Jin Seok,
Kwon Hyuk Chan,
Kim Yu Mi,
Jeong Jin Sook
Publication year - 2012
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/pin.12012
Subject(s) - fascin , lymphovascular invasion , immunohistochemistry , cancer , tissue microarray , metastasis , stage (stratigraphy) , galectin 3 , medicine , galectin , survival rate , motility , oncology , cell , cancer cell , pathology , cancer research , biology , immunology , microbiology and biotechnology , paleontology , genetics
Fascin is an actin‐binding protein that provides mechanical support and cell motility, and involves cancer cell metastasis. We investigated fascin protein expression in gastric cancer and assessed their relationship with clinicopathologic parameters and survival rates. In addition, we researched galectin‐3 protein expression to study fascin action mechanisms. We performed immunohistochemisty with fascin and galectin‐3 antibodies in 471 gastric carcinomas, using tissue microarrays. Fascin was positive in 14.9% (70/471) of the samples, and fascin expression was related to worse survival rates ( P < 0.001), high clinical stage ( P < 0.001), high T stage ( P < 0.001), nodal metastasis ( P < 0.001), lymphovascular invasion ( P = 0.001) and the intestinal type of Lauren classification ( P = 0.015). Galectin‐3 protein expression was positive in 83.9% (395/471) of the samples and was reversely correlated with fascin protein expression ( P = 0.020). Galectin‐3 expression was related to low clinical stage ( P < 0.001), but not to survival rates in multivariate analysis. In multivariate analysis, fascin expression was related to worse survival rates (HR = 1.56, P = 0.036), and can be an independent poor prognostic factor in gastric cancer.