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CRISPR/Cas9 gene drive technology to control transmission of vector‐borne parasitic infections
Author(s) -
Nateghi Rostami Mahmoud
Publication year - 2020
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/pim.12762
Subject(s) - crispr , biology , gene drive , cas9 , genome editing , vector (molecular biology) , gene , computational biology , genetics , transmission (telecommunications) , population , computer science , medicine , recombinant dna , telecommunications , environmental health
Gene drive is the process of copying of an endonuclease‐containing cassette that leads to increased frequency of inheritance of the desired traits in a targeted population. CRISPR/Cas9 technology is advancing genetic manipulation of insects in the field of gene drive experiments. The CRISPR/Cas9 drive could be engineered for genetic manipulation of parasites and/or vectors for disease control. A number of promising CRISPR/Cas9‐based gene drive strategies that interfere with parasite development or impairs the reproductive capability of the insect vector have been proposed in the laboratory for blocking transmission of malaria and leishmaniasis. Still several technical and ethical challenges remain to be addressed, and none appear insuperable in this field.