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Involvement of neutrophils in Chagas disease pathology
Author(s) -
Andrade Micássio Fernandes,
Almeida Valéria Duarte,
Souza Lara Michelly Soares,
Paiva Dayane Carla Costa,
Andrade Cléber de Mesquita,
Medeiros Fernandes Thales Allyrio Araújo
Publication year - 2018
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/pim.12593
Subject(s) - immunology , chagas disease , asymptomatic , trypanosoma cruzi , immune system , biology , parasitemia , disease , effector , inflammation , pathogenesis , medicine , pathology , malaria , parasite hosting , plasmodium falciparum , world wide web , computer science
Chagas disease (CD) is a public health problem in Latin America. The acute phase presents nonspecific symptoms and most patients recover from acute parasitemia and undergo a prolonged asymptomatic phase. Several years later, about 30% of infected individuals develop chronic cardiopathy with progressive cardiomegaly, arrhythmia, thromboembolic events and heart failure. These symptoms suggest a persistent association with the presence of inflammatory infiltrate and tissue, and cellular destruction in the heart muscle. Nevertheless, few research studies have attempted to understand the role of inflammatory cells, such as neutrophils, in establishing the pathology and progression of CD. Only recently have some studies been performed with this intention. Despite this effort, the role of neutrophils in CD is still considered controversial. This review discusses the morphological and functional characteristics of neutrophils that describes their participation in the establishment and progression of Trypanosoma cruzi infection, through the development of its effector functions, such as release of lithic components, production of oxidative agents and release of inflammatory mediators capable of modulating the host immune response.