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Complement Factor H as a potential atherogenic marker in chronic Chagas’ disease
Author(s) -
Lidani K. C. F.,
Sandri T. L.,
Andrade F. A.,
Bavia L.,
Nisihara R.,
MessiasReason I. J.
Publication year - 2018
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/pim.12537
Subject(s) - medicine , body mass index , cholesterol , lipoprotein , endocrinology , ejection fraction , immunology , heart failure
Summary We aimed to investigate the association between plasma levels of complement Factor H ( FH ) with cardiac involvement, inflammatory and cardiometabolic parameters in patients with chronic Chagas’ disease ( CD ). FH plasmatic levels were determined in 80 chronic CD patients. Glycaemic index, lipidogram (high‐density lipoprotein cholesterol HDL ‐C, low‐density lipoprotein cholesterol LDL ‐C, triglycerides and total cholesterol) and Ultrasensitive C‐Reactive Protein ( uCRP ) values were obtained from medical records. Height, weight, body mass index ( BMI ) blood pressure and left ventricular ejection fraction ( LVEF ) were obtained from echocardiography examinations. Comparisons between chronic CD clinical forms were performed using Mann‐Whitney test and correlation Spearman’s test. FH levels were correlated positively with triglycerides ( P = .001, r = .39), LDL ‐C ( P = .009, r = .3), cholesterol ( P = .02, r = .28), uCRP ( P = .029, r = .31) and BMI ( P = .008, r = .34); and negatively with HDL ‐C ( P = .03, r = −.25) levels. Dyslipidemic patients showed higher FH levels compared to normolipidemic, although no difference for FH levels was observed between chronic CD clinical forms. Alternative pathway of complement may be a link between immune response and metabolic disorders, with important immunoregulatory role in chronic CD.