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Unravelling the roles of innate lymphoid cells in cerebral malaria pathogenesis
Author(s) -
Palomo J.,
Quesniaux V. F. J.,
Togbe D.,
Reverchon F.,
Ryffel B.
Publication year - 2018
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/pim.12502
Subject(s) - plasmodium berghei , cerebral malaria , immunology , biology , malaria , innate lymphoid cell , immune system , pathogenesis , innate immune system , inflammation , immunity , plasmodium falciparum
Summary Cerebral malaria (CM) is one complication of Plasmodium parasite infection that can lead to strong inflammatory immune responses in the central nervous system (CNS), accompanied by lung inflammation and anaemia. Here, we focus on the role of the innate immune response in experimental cerebral malaria (ECM) caused by blood‐stage murine Plasmodium berghei ANKA infection. While T cells are important for ECM pathogenesis, the role of innate lymphoid cells (ILCs) is only emerging. The role of ILCs and non‐lymphoid cells, such as neutrophils and platelets, contributing to the host immune response and leading to ECM and human cerebral malaria (HCM) is reviewed.