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Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy
Author(s) -
Finlay C. M.,
Stefanska A. M.,
Coleman M. M.,
Jahns H.,
Cassidy J. P.,
McLoughlin R. M.,
Mills K. H. G.
Publication year - 2017
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/pim.12460
Subject(s) - immunology , fasciola hepatica , ovalbumin , sensitization , allergy , allergen , immunoglobulin e , biology , mucus , asthma , allergic inflammation , immune system , helminths , antibody , ecology
Summary There is evidence from epidemiology studies of a negative association between infection with helminth parasites and the development of allergy and asthma. Here, we demonstrate that the excretory/secretory products of the helminth Fasciola hepatica ( FHES ) protected mice against ovalbumin ( OVA )‐induced allergic asthma when administered at time of allergen sensitization. FHES reduced the accumulation of mucus, eosinophils and lymphocytes into the airways of allergen‐challenged mice. Furthermore, FHES treatment suppressed Th2 responses in the airways. Interestingly, systemic administration of FHES at allergen challenge had no effect on airway inflammation, demonstrating that alum‐induced Th2 response is set following initial allergen sensitization. Our findings highlight the immunomodulatory potential of molecules secreted by F. hepatica .