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Increased Fas ligand expression of peripheral B‐1 cells correlated with CD 4 + T‐cell apoptosis in filarial‐infected patients
Author(s) -
Mishra R.,
Panda S. K.,
Sahoo P. K.,
Bal M. S.,
Satapathy A. K.
Publication year - 2017
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/pim.12421
Subject(s) - fas ligand , biology , apoptosis , immunology , immune system , programmed cell death , biochemistry
Summary Cellular hyporesponsiveness observed during helminth infections is attributed to factors such as antigen‐presenting cells ( APC ) dysfunction, increased interleukin‐10( IL ‐10), regulatory T cells and induction of CD 4 + T (Th)‐cell apoptosis. Increased Fas ligand (FasL) expression on the surface of B‐1 cells and induction of apoptosis of Th cells by FasL‐expressing B‐1 cells due to helminth infection were demonstrated in murine model of helminth infection where as profile of FasL expression, Th‐cell apoptosis and correlation between these two populations of cells in clinical filariasis remain unknown. In this study, we have scored the profile of apoptotic Th‐cell population and FasL‐expressing B‐1 cells in different clinical categories of filariasis. The peripheral apoptotic T‐helper cells were significantly increased in filarial patients compared to endemic controls. Expression of FasL on the surface of peripheral B‐1 cells increased in filarial patients and positively correlated with peripheral apoptotic T‐helper cells indicating FasL‐expressing B‐1 cells may be one of the important mediators of Th‐cell apoptosis and immune anergy during filarial pathology.