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Modulation of host immune responses to Toxoplasma gondii by micro RNA s
Author(s) -
Cai Y.,
Shen J.
Publication year - 2017
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/pim.12417
Subject(s) - biology , immune modulation , immune system , host (biology) , toxoplasma gondii , rna , immunology , virology , genetics , gene , antibody
Summary To survive successfully, Toxoplasma counteracts the strictly regulated host innate response to downregulate inflammation that could be deleterious for the parasite. Micro RNA s are vital regulators of both innate and adaptive immunity, controlling the maintenance and development of immune progenitors as well as the differentiation and the functions of host mature immune cells. Thus, the complexity of mechanisms underlying the connection between Toxoplasma and host immunity has led to investigations of mi RNA s as additional key molecular players. The knowledge acquired from these studies will be useful for aiding the discovery of new targets for diagnosis or therapeutic approaches for toxoplasmosis and insight into the interaction between host and parasite.