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Resiniferatoxin lowers TNF‐α, NO and PGE 2 in the intestinal phase and the parasite burden in the muscular phase of Trichinella spiralis infection
Author(s) -
MuñozCarrillo J. L.,
MuñozEscobedo J. J.,
MaldonadoTapia C. H.,
ChávezRuvalcaba F.,
MorenoGarcía M. A.
Publication year - 2017
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/pim.12393
Subject(s) - resiniferatoxin , trichinella spiralis , biology , parasite hosting , immunology , inflammation , tumor necrosis factor alpha , in vivo , immune system , helminths , biochemistry , receptor , microbiology and biotechnology , transient receptor potential channel , world wide web , trpv1 , computer science
Summary During the course of infection with Trichinella spiralis , an inflammatory response is triggered at the intestinal level in the host, playing a crucial role in the expulsion and elimination of the parasite. However, several studies have demonstrated that this inflammatory response is harmful to the host; hence, the importance of studying molecules with therapeutic potential like resiniferatoxin, which is known to have an anti‐inflammatory effect both in vitro and in vivo. In this article, we evaluated the anti‐inflammatory activity of resiniferatoxin during the intestinal phase of T. spiralis infection by quantitatively determining the levels of TNF‐α, NO and PGE 2 as well as the percentage of eosinophils in the blood and intestinal pathology. In addition, parasite burden was determined during the muscle infection. Our results show that resiniferatoxin lowered the serum levels of TNF‐α, NO and PGE 2 , as well as the percentage of eosinophils in the blood and intestinal pathology during the intestinal infection. Moreover, resiniferatoxin also lowered the parasite burden in muscle, resulting in a reduction of the humoral response (IgG) associated to treatment with resiniferatoxin. These findings suggest a potential therapeutic use of the anti‐inflammatory effect of resiniferatoxin, which also contributes to host defence against the challenge of T. spiralis infection.