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Immunity and immune modulation elicited by the larval cestode M esocestoides vogae and its products
Author(s) -
Vendelova E.,
Lutz M. B.,
Hrčková G.
Publication year - 2015
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/pim.12216
Subject(s) - biology , immune system , in vivo , parasite hosting , immunity , in vitro , immunology , antigen , secretion , endocrinology , biochemistry , microbiology and biotechnology , world wide web , computer science
Summary Larval cestodes (metacestodes) induce long‐lasting infections leading to considerable pathology in humans and livestock. Their survival is typically associated with T h2‐biased immune responses and immunosuppressive effects and depends on the parasite's ability to excrete/secrete antigens with immunoregulatory properties. Here, M esocestoides vogae, a natural parasite of mice, is proposed as a new model species for the identification and characterization of cestode‐derived immunomodulatory factors. We followed the kinetics of immune parameters after infection with M . vogae or exposure to their excretory/secretory ( ES ) products in a permissive strain of mice. Besides, a dominant IL ‐10 production and accumulation of macrophages and eosinophils expressing mRNA for Fizz‐1, YM1 and A rg‐1, mice showed minimal IFN ‐γ and transient IL ‐4 production at early time points with a complete loss at later stages of infection. We found that serum‐free ES products without host contamination directly induced M 2 macrophages and suppressed IFN ‐γ production in vivo and in vitro . This study highlights the use of the M . vogae as a cestode infection model and its ES products as a valuable tool for the identification of new therapeutic targets for the control of larval cestodiasis.