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Does EBV alter the pathogenesis of malaria?
Author(s) -
Matar C. G.,
Jacobs N. T.,
Speck S. H.,
Lamb T. J.,
Moormann A. M.
Publication year - 2015
Publication title -
parasite immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 75
eISSN - 1365-3024
pISSN - 0141-9838
DOI - 10.1111/pim.12212
Subject(s) - immunology , malaria , biology , immunity , immune system , pathogenesis , disease , plasmodium falciparum , virus , virology , epstein–barr virus , medicine
Summary Plasmodium falciparum infections have been implicated in immune deficiencies resulting in ineffective control of E pstein– B arr virus, thereby increasing the risk of endemic B urkitt lymphoma in children. However, the impact of E pstein– B arr virus infections on the development of immunity to P . falciparum has not been studied in depth. In this review, we examine novel findings from animal co‐infection models and human immuno‐epidemiologic studies to speculate on the impact of acute gammaherpesvirus co‐infection on malarial disease severity. Children are often concurrently or sequentially infected with multiple pathogens, and this has implications for understanding the development of protective immunity as well as in the evaluation of vaccine efficacy.